Wrinkles, a natural part of aging, are most prominent on sun-exposed skin, such as the face, neck, hands, and forearms. Sun exposure is a major cause of wrinkles, especially for people with light skin. Pollutants and smoking also contribute to wrinkling. If your wrinkles bother you, you have more options than ever to help smooth them or make them less visible. Medications, skin-resurfacing techniques, injections, fillers, and surgery are all effective wrinkle treatments.